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Which reagent is used for acetylation?

Silica sulfuric acid as a mild and efficient reagent for the acetylation of alcohols in solution and under solvent-free conditions.

What is the meaning of acetylation?

Listen to pronunciation. (a-SEH-tih-LAY-shun) A chemical reaction in which a small molecule called an acetyl group is added to other molecules. Acetylation of proteins may affect how they act in the body.

Where does protein acetylation occur?

Protein acetylation typically occurs on reactive amino acids containing primary amino groups, hydroxyl groups, or sulfhydryl groups (23–31). Although acetylation of side chains of cysteines, serines, and threonines has been reported, we will focus this review on N-acetylation of primary amino groups (e.g., of lysine).

How is protein acetylation detected?

A variety of assays have been used to successfully detect the acetylation or methylation of RelA. These assays include radiolabeling the acetyl- or methyl- groups, immunoblotting with pan or site-specific acetyl- or methyl-lysine antibodies, and mass spectrometry (6, 7,16, 18, 19).

Does acetylation target proteins for destruction?

Nα-terminal acetylation (Nt-acetylation) occurs very frequently and is found in most proteins in eukaryotes. In addition, Nt-acetylation marks specific proteins for degradation by a branch of the N-end rule pathway, a subset of the ubiquitin-mediated proteolytic system.

What is acyl compound?

An acyl group is a moiety derived by the removal of one or more hydroxyl groups from an oxoacid, including inorganic acids. It contains a double-bonded oxygen atom and an alkyl group (R-C=O). In organic chemistry, the acyl group (IUPAC name: alkanoyl) is usually derived from a carboxylic acid.

What is r in organic chemistry?

R group: An abbreviation for any group in which a carbon or hydrogen atom is attached to the rest of the molecule. R is an abbreviation for radical, when the term radical applied to a portion of a complete molecule (not necessarily a free radical), such as a methyl group.