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When an indicator changes color during a titration it is a sign?

When an indicator changes colour during titration it is a sign that the end point [equivalence point] has been reached. The equivalence point of a neutralization reaction is the point at which chemically equivalent quantities of acid and base have reacted together.

What has only one endpoint?

A ray is a part of a line that has one endpoint and goes on infinitely in only one direction. You cannot measure the length of a ray. A ray is named using its endpoint first, and then any other point on the ray (for example, →BA ).

What is the endpoint of a function?

A node of a graph of degree 1 (left figure; Harary 1994, p. 15), or, a point at the boundary of line segment or closed interval (right figure).

What is the endpoint on a number line?

Endpoints are the points on either end of a line segment or on one end of a ray. In a line segment, the line does not extend past either of its endpoints that it connects.

What is an endpoint in statistics?

An endpoint is a trial outcome value that is measured for each subject, for example, objective tumour response (OR) or time to death (overall survival or OS).

What is the endpoint of a study?

In clinical trials, an event or outcome that can be measured objectively to determine whether the intervention being studied is beneficial. The endpoints of a clinical trial are usually included in the study objectives.

Can you have two primary endpoints?

Co-primary endpoints should only be used when there are more than one primary endpoint and declare the study success only if both primary endpoints are statistically significant in favor of the experimental treatment. When co-primary endpoints are used, each primary endpoint is tested at significant level of 0.05.

What is a co-primary endpoint?

Often a treatment is assessed by co-primary endpoints so that a comprehensive picture of the treatment effect can be obtained. Co-primary endpoints can be different medical assessments angled at different aspects of a disease, therefore, are used collectively to strengthen evidence for the treatment effect.

What is the difference between primary and secondary endpoints?

The primary endpoint of a clinical trial is the endpoint for which the trial is powered. Secondary endpoints are additional endpoints, preferably also pre-specified, for which the trial may not be powered.

What is a multiplicity adjustment?

Multiplicity adjustments may have to be considered for between-subject effects (e.g. differences between treatment groups), within-subject effects (e.g. within-subject differences over time) or both (e.g. difference between treatment groups and within-subject differences over time).

What does primary endpoint mean in medical terms?

(PRY-mayr-ee END-poynt) The main result that is measured at the end of a study to see if a given treatment worked (e.g., the number of deaths or the difference in survival between the treatment group and the control group).

What is the primary endpoint for a Phase 1 trial?

As an inheritance from chemotherapy drug development methodology, conventional primary endpoints of phase 1 trials are: definition of maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), and estimation of safety profile of new drugs to help guide later phase clinical trials (i.e., phase 2 and 3 trials) [12].